Danazol

Category: hormone

Aliases: Danocrine

Pharmacological Mechanism

17α-ethinyl testosterone derivative — weak androgen + suppresses pituitary FSH/LH. Used for endometriosis, hereditary angioedema, fibrocystic breast disease. Hepatotoxic + virilization at higher doses.

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 400 mg (Range: 100–800 mg)

Target Organ Systems

• endocrine
• digestive
• reproductive

Pathways It Modulates

• Hypothalamic-pituitary-gonadal axis (activator) — AR + PR partial (anti-gonadotropin)

Chemical Identifiers

• PubChem CID: 28417
• Formula: C22H27NO2
• Molecular weight: 337.47 g/mol
• InChIKey: POZRVZJJTULAOH-LHZXLZLDSA-N
• SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC5=C(C[C@]34C)C=NO5