Cyclophosphamide

Category: pharmacological

Aliases: Cytoxan

Pharmacological Mechanism

Nitrogen-mustard alkylating prodrug — CYP2B6 + CYP3A4 oxidation produces phosphoramide mustard (cytotoxic) + acrolein (urotoxic — mesna co-administration prevents hemorrhagic cystitis). Used in lymphoma + breast + lupus + vasculitis regimens.

Half-Life (t½)

PO: 4h, IV: 9h

Dosing Guidelines

• PO: Typical 100mg (Range: 50 - 100 mg)

Target Organ Systems

• digestive
• immune-hematologic