Cyclobenzaprine

Category: pharmacological

Aliases: Flexeril

Pharmacological Mechanism

Centrally-acting muscle relaxant — TCA-class structure; 5-HT2 antagonism + anticholinergic effect at brainstem reticular formation reduces tonic muscle activity. Sedating; used for acute musculoskeletal pain. Anticholinergic burden = Beers-list problematic in elderly.

Half-Life (t½)

PO: 32h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–30 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Skeletal muscle relaxants (inhibitor) — 5-HT2 antagonist + central anticholinergic (TCA structure)

Chemical Identifiers

• PubChem CID: 2895
• Formula: C20H21N
• Molecular weight: 275.39 g/mol
• InChIKey: JURKNVYFZMSNLP-UHFFFAOYSA-N
• SMILES: CN(C)CCC=C1C2=CC=CC=C2C=CC3=CC=CC=C31

References

• PMID 19243711