Cromolyn

Category: pharmacological

Aliases: Sodium cromoglicate, Intal, Crolom

Pharmacological Mechanism

Mast cell stabilizer — inhibits degranulation of pulmonary + ocular + gut mast cells. Inhaled for asthma prophylaxis (not rescue), nasal for allergic rhinitis, ophthalmic for allergic conjunctivitis, oral for systemic mastocytosis.

Half-Life (t½)

INH: 1.5h

Dosing Guidelines

• INH: Typical 4 mg (Range: 2–8 mg)

Target Organ Systems

• respiratory
• immune-hematologic

Pathways It Modulates

• Mast cell stabilization + leukotriene axis (inhibitor) — mast cell stabilizer (mechanism debated)

Chemical Identifiers

• PubChem CID: 2882
• Formula: C23H16O11
• Molecular weight: 468.37 g/mol
• InChIKey: IMZMKUWMOSJXDT-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)O)O)C(=O)C=C(O2)C(=O)O