Clotrimazole

Category: topical

Aliases: Lotrimin, Mycelex

Pharmacological Mechanism

Imidazole topical antifungal — fungal CYP51 (lanosterol 14α-demethylase) inhibitor blocking ergosterol synthesis. OTC for tinea + cutaneous candidiasis + vaginal candidiasis. Minimal systemic absorption from topical route.

Half-Life (t½)

TD: 4h

Dosing Guidelines

• TD: Typical 10mg (Range: 10 - 20 mg)

Target Organ Systems

• digestive
• reproductive
• integumentary
• immune-hematologic