Clomipramine

Category: pharmacological

Aliases: Anafranil

Pharmacological Mechanism

TCA with strongest serotonergic activity in the class — first-line TCA for OCD. Active demethyl-clomipramine metabolite contributes NE reuptake inhibition. Same anticholinergic burden as other TCAs.

Half-Life (t½)

PO: 32h

Dosing Guidelines

• PO: Typical 100mg (Range: 25 - 250 mg)

Target Organ Systems

• nervous