Mixture of zuclomiphene + enclomiphene isomers. Antagonizes estrogen receptor at the hypothalamus, removing negative feedback → increased GnRH → increased FSH/LH → increased gonadal steroid output. In women, induces ovulation; in men, raises endogenous testosterone without exogenous androgen exposure.
Half-Life (t½)
PO: 120h
Dosing Guidelines
PO: Typical 83.3 mg (Range: 50–150 mg)
Target Organ Systems
nervous
endocrine
reproductive
Interactions
Tamoxifen (caution): both SERMs with overlapping ER modulation — combination not standard; clomiphene's hypothalamic-axis effects may complicate breast cancer ER blockade