Clomiphene

Category: pharmacological

Aliases: Clomid, Serophene, clomiphene citrate

Pharmacological Mechanism

Mixture of zuclomiphene + enclomiphene isomers. Antagonizes estrogen receptor at the hypothalamus, removing negative feedback → increased GnRH → increased FSH/LH → increased gonadal steroid output. In women, induces ovulation; in men, raises endogenous testosterone without exogenous androgen exposure.

Half-Life (t½)

PO: 120h

Dosing Guidelines

Target Organ Systems

Interactions