Clobetasol Propionate

Category: topical

Aliases: Temovate

Pharmacological Mechanism

Super-high-potency topical glucocorticoid (Class I — most potent) — fluorinated + chlorinated steroid. Reserved for severe psoriasis, lichen planus, recalcitrant dermatitis. Two-week max courses on limited body areas to avoid HPA axis suppression and skin atrophy.

Half-Life (t½)

TD: 6h

Dosing Guidelines

• TD: Typical 0.05 mg (Range: 0.05–0.5 mg)

Target Organ Systems

• endocrine
• musculoskeletal
• integumentary

Pathways It Modulates

• Topical anti-inflammatory skin Rx (inhibitor) — GR — super-potent class I TCS (psoriasis short-burst + lichen)

Chemical Identifiers

• PubChem CID: 32798
• Formula: C25H32ClFO5
• Molecular weight: 467 g/mol
• InChIKey: CBGUOGMQLZIXBE-XGQKBEPLSA-N
• SMILES: CCC(=O)O[C@@]1([C@H](C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)C)C(=O)CCl