Clindamycin

Category: pharmacological

Aliases: Cleocin

Pharmacological Mechanism

Lincosamide antibiotic — binds 50S ribosomal subunit (overlapping macrolide site) blocking translocation. Anaerobic + gram-positive coverage. Highest C. difficile infection signal among antibiotics. CYP3A4 substrate.

Half-Life (t½)

PO: 3h, IV: 3h, IM: 3h

Dosing Guidelines

• PO: Typical 300mg (Range: 150 - 450 mg)

Target Organ Systems

• digestive
• immune-hematologic