Clindamycin

Category: pharmacological

Aliases: Cleocin

Pharmacological Mechanism

Lincosamide antibiotic — binds 50S ribosomal subunit (overlapping macrolide site) blocking translocation. Anaerobic + gram-positive coverage. Highest C. difficile infection signal among antibiotics. CYP3A4 substrate.

Half-Life (t½)

PO: 3h, IV: 3h, IM: 3h

Dosing Guidelines

• PO: Typical 300 mg (Range: 150–450 mg)

Target Organ Systems

• digestive
• immune-hematologic

Pathways It Modulates

• Bacterial ribosome (inhibitor) — 50S (23S rRNA, near macrolide site)

Chemical Identifiers

• PubChem CID: 446598
• Formula: C18H33ClN2O5S
• Molecular weight: 424.98 g/mol
• InChIKey: KDLRVYVGXIQJDK-AWPVFWJPSA-N
• SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)O)O)O)[C@H](C)Cl

References

• PMID 10475141