Clenbuterol

Category: pharmacological

Aliases: Clen

Pharmacological Mechanism

Long-acting selective β2-adrenergic receptor agonist (Gs/cAMP). Bronchodilator (approved abroad, not for human use in the US). Abused off-label for fat loss via β2-mediated lipolysis, thermogenesis, and a repartitioning/mild anabolic effect on skeletal muscle. Adverse effects: tachycardia, tremor, hypokalemia, and cardiac hypertrophy/arrhythmia risk; the long half-life prolongs toxicity.

Half-Life (t½)

PO: 35h

Dosing Guidelines

• PO: Typical 40 mcg (Range: 20–120 mcg)

Target Organ Systems

• respiratory
• cardiovascular
• musculoskeletal
• nervous

Notes

PubChem CID 2783 (free base). NOT a steroid — a β2-agonist. Doses are in MICROGRAMS (20–120 µg/day). PK: Yamamoto 1985 (PMID:4045696) verbatim "The half-life of clenbuterol in plasma was estimated to be about 35 h" in man after oral clenbuterol HCl.

Chemical Identifiers

• PubChem CID: 2783
• Formula: C12H18Cl2N2O
• Molecular weight: 277.19 g/mol
• InChIKey: STJMRWALKKWQGH-UHFFFAOYSA-N
• SMILES: CC(C)(C)NCC(C1=CC(=C(C(=C1)Cl)N)Cl)O

References

• PMID 4045696