Cilostazol

Category: pharmacological

Aliases: Pletal

Pharmacological Mechanism

Selective phosphodiesterase 3 inhibitor — raises platelet + smooth muscle cAMP. Vasodilator + antiplatelet. Used for symptomatic relief of intermittent claudication. Contraindicated in heart failure (PDE3 inhibitors increase mortality in HFrEF).

Half-Life (t½)

PO: 11h

Dosing Guidelines

• PO: Typical 100mg (Range: 50 - 200 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic