Cilostazol

Category: pharmacological

Aliases: Pletal

Pharmacological Mechanism

Selective phosphodiesterase 3 inhibitor — raises platelet + smooth muscle cAMP. Vasodilator + antiplatelet. Used for symptomatic relief of intermittent claudication. Contraindicated in heart failure (PDE3 inhibitors increase mortality in HFrEF).

Half-Life (t½)

PO: 11h

Dosing Guidelines

• PO: Typical 100 mg (Range: 50–200 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic

Pathways It Modulates

• cAMP / PKA second-messenger signaling (inhibitor) — PDE3
• Platelet aggregation (inhibitor) — PDE3

Chemical Identifiers

• PubChem CID: 2754
• Formula: C20H27N5O2
• Molecular weight: 369.46 g/mol
• InChIKey: RRGUKTPIGVIEKM-UHFFFAOYSA-N
• SMILES: C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4

References

• PMID 10702882
• PMID 12180353