Ciclesonide

Category: pharmacological

Aliases: Alvesco

Pharmacological Mechanism

Inhaled corticosteroid prodrug — activated by lung esterases to des-ciclesonide. Lung-specific activation reduces oropharyngeal candidiasis + dysphonia vs other ICS. Once-daily dosing.

Half-Life (t½)

INH: 6h

Dosing Guidelines

• INH: Typical 0.16 mg (Range: 0.08–0.32 mg)

Target Organ Systems

• respiratory

Pathways It Modulates

• Asthma (inhibitor) — GR (ICS, on-site activation in lung — lower systemic effect)
• Glucocorticoid receptor (GR) signaling (activator) — GR (inhaled prodrug → des-ciclesonide)

Chemical Identifiers

• PubChem CID: 6918155
• Formula: C32H44O7
• Molecular weight: 540.69 g/mol
• InChIKey: LUKZNWIVRBCLON-GXOBDPJESA-N
• SMILES: CC(C)C(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)O[C@H](O2)C6CCCCC6