Non-absorbed quaternary-ammonium resin that binds bile acids in the gut → prevents reabsorption → increases hepatic conversion of cholesterol → bile acids → LDLR upregulation → LDL clearance. Older agent with poor tolerability.
Dosing Guidelines
PO: Typical 10.7 g (Range: 4–24 g)
Target Organ Systems
cardiovascular
digestive
Interactions
Warfarin (caution): Binds warfarin — separate dosing by ≥4 h. [Holbrook 2005]
Levothyroxine (caution): Binds T4 — separate by ≥4 h.
Pathways It Modulates
Bile acid (inhibitor) — BA sequestrant → ↑BA synthesis + altered microbial substrate