Centrophenoxine

Category: nootropic

Aliases: Meclofenoxate, Lucidril

Pharmacological Mechanism

Ester of DMAE (dimethylaminoethanol) + p-chlorophenoxyacetic acid. Hydrolyses to DMAE which crosses BBB → cholinergic effects (weak choline precursor). Also removes lipofuscin (age pigment) in preclinical studies — the 'anti-aging' rationale.

Dosing Guidelines

• PO: Typical 667 mg (Range: 250–1500 mg)

Target Organ Systems

• nervous
• integumentary

Pathways It Modulates

• AMPA + kainate glutamate receptor modulation (activator) — DMAE prodrug → CNS choline + lipofuscin reduction

Chemical Identifiers

• PubChem CID: 19379
• Formula: C12H17Cl2NO3
• Molecular weight: 257.71 g/mol
• InChIKey: FIVHOHCAXWQPGC-UHFFFAOYSA-N
• SMILES: CN(C)CCOC(=O)COC1=CC=C(C=C1)Cl.Cl

References

• PMID 18840370