Cefuroxime

Category: pharmacological

Aliases: Ceftin, Zinacef

Pharmacological Mechanism

Second-generation cephalosporin β-lactam — better gram-negative + β-lactamase stability than first-generation. Oral axetil prodrug + IV form. Common for acute otitis media + bronchitis + Lyme disease (early).

Half-Life (t½)

PO: 1.5h, IV: 1.5h

Dosing Guidelines

• PO: Typical 500 mg (Range: 250–500 mg)

Target Organ Systems

• respiratory
• immune-hematologic

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP (2nd-gen cephalosporin)

Chemical Identifiers

• PubChem CID: 5479529
• Formula: C16H16N4O8S
• Molecular weight: 424.39 g/mol
• InChIKey: JFPVXVDWJQMJEE-IZRZKJBUSA-N
• SMILES: CO/N=C(/C1=CC=CO1)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)N)C(=O)O

References

• PMID 14696789