Ceftriaxone

Category: pharmacological

Aliases: Rocephin

Pharmacological Mechanism

Third-generation cephalosporin β-lactam — extended gram-negative + good gram-positive coverage. Once-daily IV/IM dosing makes it a workhorse for inpatient pneumonia, meningitis (CSF penetration), gonorrhea single-dose. Biliary > renal clearance — sludging in gallbladder.

Half-Life (t½)

IV: 8h, IM: 8.1h

Dosing Guidelines

• IV: Typical 1000 mg (Range: 500–2000 mg)

Target Organ Systems

• digestive
• renal

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP (3rd-gen cephalosporin)

Chemical Identifiers

• PubChem CID: 5479530
• Formula: C18H18N8O7S3
• Molecular weight: 554.58 g/mol
• InChIKey: VAAUVRVFOQPIGI-SPQHTLEESA-N
• SMILES: CN1C(=NC(=O)C(=O)N1)SCC2=C(N3[C@@H]([C@@H](C3=O)NC(=O)/C(=N\OC)/C4=CSC(=N4)N)SC2)C(=O)O

References

• PMID 3985603