Cannabidiol

Category: alkaloid

Aliases: CBD, Epidiolex

Pharmacological Mechanism

Non-psychoactive phytocannabinoid — weak CB1/CB2 affinity but allosteric negative modulator of CB1; agonist at TRPV1, 5-HT1A; modulator of GPR55, adenosine reuptake. FDA-approved (Epidiolex) for Dravet + Lennox-Gastaut + tuberous sclerosis seizures. Strong CYP2C19 + CYP3A4 inhibitor at therapeutic doses.

Half-Life (t½)

PO: 60h, INH: 24h

Dosing Guidelines

• PO: Typical 25 mg (Range: 5–50 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• Endocannabinoid system (activator) — CB2 weak + GPR55 + 5-HT1A + TRPV1 (multi-target)

Chemical Identifiers

• PubChem CID: 644019
• Formula: C21H30O2
• Molecular weight: 314.46 g/mol
• InChIKey: QHMBSVQNZZTUGM-ZWKOTPCHSA-N
• SMILES: CCCCCC1=CC(=C(C(=C1)O)[C@@H]2C=C(CC[C@H]2C(=C)C)C)O

References

• PMID 30534073
• PMID 17245363