Category: pharmacological
Aliases: Vraylar, Reagila, RGH-188
D3-preferring D3/D2 partial agonist with high D3 affinity (in vivo brain D3 occupancy at therapeutic doses — unusual among antipsychotics). Also 5-HT1A partial agonism and 5-HT2B antagonism. Two active metabolites: desmethyl-cariprazine (DCAR) and didesmethyl-cariprazine (DDCAR); DDCAR has a multi-week terminal half-life, giving cariprazine uniquely long effective duration after discontinuation.
PO: 72h