Calcipotriene

Category: topical

Aliases: Calcipotriol, Dovonex

Pharmacological Mechanism

Topical vitamin D3 analog — VDR agonist on keratinocytes that normalizes hyperproliferation in psoriasis. Often combined with topical corticosteroid (calcipotriene + betamethasone, Taclonex) for synergistic plaque reduction.

Half-Life (t½)

TD: 14h

Dosing Guidelines

• TD: Typical 0.05mg (Range: 0.05 - 0.5 mg)

Target Organ Systems

• endocrine
• integumentary