Caffeic Acid

Category: polyphenol

Aliases: 3,4-dihydroxycinnamic acid

Pharmacological Mechanism

Hydroxycinnamic acid — dietary phenolic in coffee, fruits. Strong antioxidant; inhibits 5-lipoxygenase reducing leukotriene synthesis. Hepatoprotective in animal toxicology models.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 200 mg (Range: 100–500 mg)

Target Organ Systems

• cardiovascular
• immune-hematologic

Pathways It Modulates

• Nrf2 / Keap1 antioxidant response (activator) — Nrf2 + COX-2

Chemical Identifiers

• PubChem CID: 689043
• Formula: C9H8O4
• Molecular weight: 180.16 g/mol
• InChIKey: QAIPRVGONGVQAS-DUXPYHPUSA-N
• SMILES: C1=CC(=C(C=C1/C=C/C(=O)O)O)O