Brimonidine

Category: pharmacological

Aliases: Alphagan

Pharmacological Mechanism

Selective α2-adrenergic agonist (ophthalmic) — reduces aqueous humor production + increases uveoscleral outflow. Used in open-angle glaucoma + ocular hypertension. Topical rosacea formulation (Mirvaso) uses the same compound for vasoconstrictive erythema reduction.

Half-Life (t½)

TD: 3h

Dosing Guidelines

• TD: Typical 0.2 mg (Range: 0.1–0.2 mg)

Target Organ Systems

• cardiovascular
• integumentary

Pathways It Modulates

• Aqueous humor / IOP regulation (activator) — α2-adrenergic (reduces aqueous production + increases uveoscleral outflow)

Chemical Identifiers

• PubChem CID: 2435
• Formula: C11H10BrN5
• Molecular weight: 292.13 g/mol
• InChIKey: XYLJNLCSTIOKRM-UHFFFAOYSA-N
• SMILES: C1CN=C(N1)NC2=C(C3=NC=CN=C3C=C2)Br

References

• PMID 9605427