Beclomethasone

Category: pharmacological

Aliases: QVAR, Beconase

Pharmacological Mechanism

Inhaled / intranasal corticosteroid — high topical glucocorticoid potency + extensive first-pass deactivation. Asthma maintenance + allergic rhinitis. One of the older inhaled corticosteroids, broadly affordable.

Half-Life (t½)

INH: 3h

Dosing Guidelines

• INH: Typical 0.16 mg (Range: 0.04–0.32 mg)

Target Organ Systems

• respiratory
• digestive
• immune-hematologic

Pathways It Modulates

• Asthma (inhibitor) — GR (ICS, prodrug)
• Glucocorticoid receptor (GR) signaling (activator) — GR (inhaled)

Chemical Identifiers

• PubChem CID: 20469
• Formula: C22H29ClO5
• Molecular weight: 408.92 g/mol
• InChIKey: NBMKJKDGKREAPL-DVTGEIKXSA-N
• SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)Cl)C