Baloxavir Marboxil

Category: pharmacological

Aliases: Xofluza

Pharmacological Mechanism

Influenza cap-dependent endonuclease (PA subunit) inhibitor — blocks viral mRNA synthesis. Single-dose oral therapy advantage over oseltamivir (5-day course). Reduced influenza A activity in some 2021 strains via PA I38T resistance mutation.

Half-Life (t½)

PO: 80h

Dosing Guidelines

• PO: Typical 40mg (Range: 40 - 80 mg)

Target Organ Systems

• immune-hematologic