Category: pharmacological
Aliases: Imuran
Prodrug of 6-mercaptopurine — incorporated into DNA as thioguanine nucleotides causing immunosuppression. TPMT polymorphism (~10% intermediate, ~0.3% deficient) drives marked toxicity variability — pre-treatment TPMT/NUDT15 genotyping standard. IBD + autoimmune + steroid-sparing transplant maintenance.
PO: 5h