Atropine

Category: alkaloid

Pharmacological Mechanism

Tropane alkaloid from Atropa belladonna. Competitive muscarinic receptor antagonist (M1–M5). Used for bradycardia (IV), pupillary dilation (ophthalmic), and nerve agent / organophosphate poisoning.

Half-Life (t½)

IV: 4h

Dosing Guidelines

• IV: Typical 1 mg (Range: 0.5–1 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Autonomic nervous system balance (inhibitor) — muscarinic (parasympathetic arm — rescue bradycardia)
• Muscarinic ACh receptor subtypes (inhibitor) — M1–M5 non-selective (acute — anticholinergic toxidrome reversal, ACLS bradycardia)

Chemical Identifiers

• PubChem CID: 174174
• Formula: C17H23NO3
• Molecular weight: 289.37 g/mol
• InChIKey: RKUNBYITZUJHSG-PJPHBNEVSA-N
• SMILES: CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3