Atracurium

Category: pharmacological

Aliases: Tracrium

Pharmacological Mechanism

Benzylisoquinolinium non-depolarizing neuromuscular blocker — competitive nicotinic ACh antagonist. Cleared by Hofmann elimination + ester hydrolysis (organ-independent), making it useful in renal/hepatic failure. Histamine release at high IV bolus.

Half-Life (t½)

IV: 0.33h

Dosing Guidelines

• IV: Typical 0.5mg (Range: 0.4 - 0.5 mg)

Target Organ Systems

• nervous
• digestive
• renal