Atenolol

Category: pharmacological

Aliases: Tenormin

Pharmacological Mechanism

Cardioselective β₁ antagonist; negligible β₂ at therapeutic doses. Hydrophilic → low CNS penetration (less nightmares / depression than propranolol). Renal elimination — accumulates in CKD.

Half-Life (t½)

PO: 6h

Dosing Guidelines

• PO: Typical 50 mg (Range: 25–100 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — β1-cardioselective

Chemical Identifiers

• PubChem CID: 2249
• Formula: C14H22N2O3
• Molecular weight: 266.34 g/mol
• InChIKey: METKIMKYRPQLGS-UHFFFAOYSA-N
• SMILES: CC(C)NCC(COC1=CC=C(C=C1)CC(=O)N)O

References

• PMID 1982759
• PMID 15060759