Argireline

Category: peptide

Aliases: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8

Pharmacological Mechanism

Synthetic hexapeptide modeled on the SNAP-25 N-terminus — competes with SNAP-25 for SNARE-complex assembly, weakly inhibiting facial-muscle acetylcholine release. Topical "Botox-in-a-jar" cosmetic claim with modest evidence; benefit confined to expression-line softening.

Half-Life (t½)

TD: 6h

Dosing Guidelines

• TD: Typical 5 mg (Range: 2–10 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Antimicrobial + cosmetic peptides (inhibitor) — SNAP-25 / SNARE complex

Chemical Identifiers

• PubChem CID: 71587772
• Formula: C35H62N14O11S
• Molecular weight: 888.99 g/mol
• InChIKey: AJLNZWYOJAWBCR-OOPVGHQCSA-N
• SMILES: CC(=O)N[C@@H](CCC(=O)O)C(=C)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N