Amoxicillin

Category: pharmacological

Aliases: Amoxil

Pharmacological Mechanism

β-lactam — inhibits transpeptidase (PBP) crosslinking peptidoglycan in bacterial cell wall. Broader gram-negative coverage than penicillin. Renally cleared; no CYP. Allergy cross-reactivity with cephalosporins.

Half-Life (t½)

PO: 1.5h, IV: 1.5h

Dosing Guidelines

• PO: Typical 500 mg (Range: 250–1000 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• Bacterial cell wall (inhibitor) — PBP (β-lactam)

Chemical Identifiers

• PubChem CID: 33613
• Formula: C16H19N3O5S
• Molecular weight: 365.4 g/mol
• InChIKey: LSQZJLSUYDQPKJ-NJBDSQKTSA-N
• SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)[C@@H](C3=CC=C(C=C3)O)N)C(=O)O)C