Amitriptyline

Category: pharmacological

Aliases: Elavil

Pharmacological Mechanism

Tertiary-amine TCA — strong serotonin + norepinephrine reuptake inhibition + H1 + muscarinic + α1 antagonism. Now used mainly off-label for chronic pain, migraine prophylaxis, neuropathic pain at low doses (10–50 mg). High anticholinergic burden in elderly.

Half-Life (t½)

PO: 21h

Dosing Guidelines

• PO: Typical 50mg (Range: 10 - 150 mg)

Target Organ Systems

• nervous