Amiodarone

Category: pharmacological

Aliases: Cordarone, Pacerone

Pharmacological Mechanism

Class III antiarrhythmic — multi-channel blocker (K+, Na+, Ca²⁺, β-adrenergic). Inhibits CYP3A4, CYP2C9, CYP2D6, P-gp — broad DDI profile. Massive Vd (~60 L/kg) and extreme half-life (~40-50 days) require months for steady-state and washout. Pulmonary, hepatic, thyroid toxicity at chronic exposure.

Half-Life (t½)

PO: 1080h, IV: 1080h

Dosing Guidelines

• PO: Typical 200mg (Range: 100 - 400 mg)

Target Organ Systems

• respiratory
• endocrine
• digestive

Interactions

• Digoxin
• Simvastatin
• Warfarin
• Flecainide
• Metoprolol
• Phenytoin