Alogliptin

Category: pharmacological

Aliases: Nesina

Pharmacological Mechanism

DPP-4 inhibitor — same mechanism as sitagliptin, linagliptin, saxagliptin (raises endogenous GLP-1 + GIP). Renal dose adjustment needed. Heart failure signal in EXAMINE trial led to FDA boxed warning.

Half-Life (t½)

PO: 21h

Dosing Guidelines

• PO: Typical 25mg (Range: 6.25 - 25 mg)

Target Organ Systems

• cardiovascular
• endocrine
• renal