Allicin

Category: metabolite

Pharmacological Mechanism

Diallyl thiosulfinate formed when fresh garlic is crushed (alliin + alliinase enzymatic conversion). Antimicrobial, modest blood-pressure lowering, weak antiplatelet. Highly unstable — degrades to ajoene + diallyl sulfides during heating + GI transit.

Half-Life (t½)

PO: 1h

Dosing Guidelines

• PO: Typical 10 mg (Range: 5–15 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• Glutathione synthesis + redox cycle (inhibitor) — HMG-CoA reductase + antimicrobial (garlic)

Chemical Identifiers

• PubChem CID: 65036
• Formula: C6H10OS2
• Molecular weight: 162.27 g/mol
• InChIKey: JDLKFOPOAOFWQN-UHFFFAOYSA-N
• SMILES: C=CCSS(=O)CC=C