Alendronate

Category: pharmacological

Aliases: Fosamax

Pharmacological Mechanism

Aminobisphosphonate — incorporates into hydroxyapatite + inhibits farnesyl pyrophosphate synthase in osteoclasts → osteoclast apoptosis → reduced bone resorption. First-line oral therapy for postmenopausal osteoporosis. Esophageal irritation requires upright positioning + 30 min fast post-dose.

Half-Life (t½)

PO: 240h

Dosing Guidelines

Target Organ Systems