Agomelatine

Category: pharmacological

Aliases: Valdoxan

Pharmacological Mechanism

Atypical antidepressant — melatonin MT1/MT2 agonist + 5-HT2C antagonist. Resynchronizes circadian rhythm in depression with sleep architecture disruption. Hepatotoxicity warning requires LFT monitoring.

Half-Life (t½)

PO: 0.96h

Dosing Guidelines

• PO: Typical 25mg (Range: 25 - 50 mg)

Target Organ Systems

• nervous
• digestive