Agomelatine

Category: pharmacological

Aliases: Valdoxan

Pharmacological Mechanism

Atypical antidepressant — melatonin MT1/MT2 agonist + 5-HT2C antagonist. Resynchronizes circadian rhythm in depression with sleep architecture disruption. Hepatotoxicity warning requires LFT monitoring.

Half-Life (t½)

PO: 0.96h

Dosing Guidelines

• PO: Typical 25 mg (Range: 25–50 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• BDNF / TrkB neurotrophic signaling (activator) — BDNF (via MT1/MT2 + 5-HT2C antagonism)
• Circadian clock (activator) — MT1 / MT2 + 5-HT2C antagonist
• Tricyclic + atypical antidepressants (activator) — MT1 + MT2 + 5-HT2C antagonist

Chemical Identifiers

• PubChem CID: 82148
• Formula: C15H17NO2
• Molecular weight: 243.3 g/mol
• InChIKey: YJYPHIXNFHFHND-UHFFFAOYSA-N
• SMILES: CC(=O)NCCC1=CC=CC2=C1C=C(C=C2)OC

References

• PMID 28392509