Agmatine

Category: metabolite

Aliases: 4-Aminobutylguanidine, Agmatine sulfate

Pharmacological Mechanism

Decarboxylated arginine (arginine decarboxylase). Imidazoline I1/I2 receptor ligand; NMDA receptor antagonist at nitric-oxide site; α₂-adrenergic partial agonist. Proposed neuropathic-pain and mood-modulating effects, preclinical-dominant evidence.

Dosing Guidelines

• PO: Typical 1167 mg (Range: 500–2500 mg)

Target Organ Systems

• nervous

Interactions

• Arginine (synergistic): Direct precursor via arginine decarboxylase.

Pathways It Modulates

• Histamine synthesis + degradation (inhibitor) — NMDA + α2-adrenergic + NOS modulation

Chemical Identifiers

• PubChem CID: 199
• Formula: C5H14N4
• Molecular weight: 130.19 g/mol
• InChIKey: QYPPJABKJHAVHS-UHFFFAOYSA-N
• SMILES: C(CCN=C(N)N)CN

References

• PMID 8786560
• PMID 7715734
• PMID 8930173
• PMID 15982768
• PMID 37770201
• PMID 20447305
• PMID 23769988