Category: biologic
Aliases: Humira, anti-TNFα mAb
Fully human IgG1 mAb binding soluble and membrane-bound TNFα → neutralises TNF-mediated pro-inflammatory signalling through TNFR1/2. First fully human therapeutic antibody (phage-display discovery). Clinical impact spans rheumatology, dermatology, and gastroenterology. Once the world's best-selling drug; multiple biosimilars now available.
SC: 312h