Aclidinium

Category: pharmacological

Aliases: Tudorza

Pharmacological Mechanism

Inhaled long-acting muscarinic antagonist (LAMA) — quaternary ammonium for minimal systemic exposure. Twice-daily dosing for COPD maintenance. Rapid plasma hydrolysis vs tiotropium's slow dissociation drives the dosing-frequency difference.

Half-Life (t½)

INH: 2h

Dosing Guidelines

• INH: Typical 0.4 mg (Range: 0.4–0.4 mg)

Target Organ Systems

• nervous
• respiratory

Pathways It Modulates

• Acetylcholine synthesis + degradation (inhibitor) — muscarinic M3 (bronchial)
• Asthma (inhibitor) — M3 (LAMA)
• Muscarinic ACh receptor subtypes (inhibitor) — M3 LAMA

Chemical Identifiers

• PubChem CID: 11434515
• Formula: C26H30NO4S2+
• Molecular weight: 564.77 g/mol
• InChIKey: ASMXXROZKSBQIH-VITNCHFBSA-N
• SMILES: C1C[N+]2(CCC1[C@H](C2)OC(=O)C(C3=CC=CS3)(C4=CC=CS4)O)CCCOC5=CC=CC=C5