5-MeO-DMT

Category: alkaloid

Aliases: 5-MeO-DMT, 5-methoxy-N,N-dimethyltryptamine, O-methyl-bufotenin, toad venom

Pharmacological Mechanism

Very fast, very potent tryptamine psychedelic. A serotonergic agonist with affinity rank 5-HT1A >> 5-HT2A (5-HT1A is the primary high-affinity target, ~300-fold over 5-HT2A). O-demethylated by CYP2D6 to bufotenine and an MAO substrate. Found in Bufo alvarius (Sonoran toad) venom. Risks: extreme intensity, transient hypertension, rare serotonin toxicity when MAOI-combined.

Half-Life (t½)

IN: 0.45h

Dosing Guidelines

• INH: Typical 12 (Range: 6–20)
• IN: Typical 8 (Range: 1–12)

Target Organ Systems

• nervous

Notes

PubChem CID 1832. PK: Rucker 2024 (PMID:38616411) verbatim "the mean terminal elimination half-life was <27 min" (Tmax ~8–10 min) for intranasal BPL-003 5-MeO-DMT benzoate; authored as 0.45 h. 5-HT2A occupancy not authored — 5-HT2A is the weak target (5-HT1A primary) and its Ki is table-only (see AUTHORING_GAPS).

Chemical Identifiers

• PubChem CID: 1832
• Formula: C13H18N2O
• Molecular weight: 218.29 g/mol
• InChIKey: ZSTKHSQDNIGFLM-UHFFFAOYSA-N
• SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)OC

References

• PMID 38616411