Category: pharmacological
Aliases: 5-FU, Adrucil
Pyrimidine antimetabolite — converted intracellularly to FdUMP (irreversible thymidylate-synthase inhibitor) and FUTP (RNA misincorporation). Backbone of colorectal, breast, GI cancer regimens. DPYD deficiency causes life-threatening toxicity (mandatory testing in some EU countries).
IV: 0.23h