Verapamil

Category: pharmacological

Aliases: Calan, Isoptin

Pharmacological Mechanism

Non-dihydropyridine CCB — strongest cardiac (AV-nodal) effect of the class. Used for AF rate control, certain SVTs, hypertension, and migraine prophylaxis. Strong CYP3A4 + P-glycoprotein inhibitor → major DDI source. Constipation (~25%).

Half-Life (t½)

PO: 5h, IV: 2.36h

Dosing Guidelines

• PO: Typical 240mg (Range: 80 - 480 mg)

Target Organ Systems

• nervous
• cardiovascular
• digestive

Interactions

• Simvastatin
• Buspirone
• Midazolam