Quinidine

Category: pharmacological

Pharmacological Mechanism

Class IA antiarrhythmic + Na+ + K+ channel blocker; also potent CYP2D6 + P-glycoprotein inhibitor → classic raises-digoxin example. Dextrorotatory stereoisomer of quinine. Largely supplanted by safer antiarrhythmics.

Half-Life (t½)

PO: 10.34h, IV: 10.34h

Dosing Guidelines

• PO: Typical 300mg (Range: 200 - 600 mg)

Target Organ Systems

• digestive

Interactions

• Digoxin
• Dextromethorphan
• Propafenone
• Desipramine