Posaconazole

Category: pharmacological

Aliases: Noxafil

Pharmacological Mechanism

Broad-spectrum triazole (mucormycosis coverage). Strong CYP3A4 inhibitor without significant CYP2C9/2C19 effect — narrower DDI profile than voriconazole. Delayed-release tablet improved absorption over the older suspension formulation.

Half-Life (t½)

PO: 35h, IV: 35h

Dosing Guidelines

• PO: Typical 300mg (Range: 100 - 400 mg)

Target Organ Systems

• digestive

Interactions

• Midazolam
• Tacrolimus
• Sirolimus