Fluvoxamine

Category: pharmacological

Aliases: Luvox

Pharmacological Mechanism

SSRI — also a strong CYP1A2 inhibitor (raises clozapine, theophylline, melatonin, caffeine to clinically meaningful degrees). FDA-approved for OCD; off-label for depression + early COVID-19 (the "TOGETHER" trial).

Half-Life (t½)

PO: 16h

Dosing Guidelines

• PO: Typical 100mg (Range: 50 - 300 mg)

Target Organ Systems

• nervous
• endocrine
• digestive

Interactions

• Caffeine
• Theophylline
• Melatonin
• Olanzapine
• Duloxetine
• Ramelteon
• Tizanidine
• Clozapine
• Tacrine