Fluoxetine

Category: pharmacological

Aliases: Prozac, Sarafem

Pharmacological Mechanism

Selective serotonin reuptake inhibitor — blocks SERT. Active metabolite norfluoxetine has 7–15 day t½, buffering missed doses + causing prolonged withdrawal. Weak 5-HT2C antagonism contributes to activation / norepinephrine release. CYP2D6 inhibitor (strong) — interaction-rich.

Half-Life (t½)

PO: 48h

Dosing Guidelines

• PO: Typical 40mg (Range: 20 - 80 mg)

Target Organ Systems

• nervous
• digestive

Interactions

• St. John's Wort
• Desipramine
• Risperidone