Bupropion

Category: pharmacological

Aliases: Wellbutrin, Zyban, Aplenzin

Pharmacological Mechanism

Norepinephrine + dopamine reuptake inhibitor with nicotinic-ACh-receptor antagonism (mechanism behind smoking-cessation indication). Active hydroxybupropion metabolite contributes. No sexual side effects and mild weight-neutral-to-loss profile → often chosen when SSRI sexual dysfunction is a problem.

Half-Life (t½)

PO: 14h

Dosing Guidelines

Target Organ Systems

Interactions