Category: polyphenol
Aliases: UA, Mitopure
Formed by gut microbiota from dietary ellagitannins (pomegranate, walnut, raspberry) via a multi-step conversion to urolithin A. Critical caveat: only ~30–40% of adults are 'urolithin producers' depending on gut composition — explaining the pomegranate trial heterogeneity and the rationale for direct UA supplementation. Potent mitophagy inducer — selectively removes damaged mitochondria via PINK1-Parkin and BNIP3 pathways. Preclinical lifespan extension + muscle-function data.
PO: 20h