Thiamine

Category: vitamin

Aliases: Vitamin B1, Thiamine HCl, Thiamine mononitrate

Pharmacological Mechanism

Phosphorylated to thiamine pyrophosphate (TPP), the coenzyme for pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, branched-chain α-keto acid dehydrogenase, and transketolase (pentose phosphate pathway). Deficiency causes beriberi (wet/dry) and Wernicke-Korsakoff syndrome — critical to give BEFORE glucose in suspected alcoholic presentations.

Half-Life (t½)

PO: 10h, IV: 10h

Dosing Guidelines

• PO: Typical 1.13mg (Range: 1.1 - 1.2 mg)
• IM: Typical 1.13mg (Range: 1.1 - 1.2 mg)
• IV: Typical 1.13mg (Range: 1.1 - 1.2 mg)

Target Organ Systems

• nervous

Interactions

• Benfotiamine