Benfotiamine

Category: vitamin

Aliases: S-Benzoylthiamine O-monophosphate, Lipid-soluble B1

Pharmacological Mechanism

Lipid-soluble thiamine prodrug. Hydrolysed by intestinal alkaline phosphatase to S-benzoylthiamine, which diffuses passively across membranes — bypasses the saturable SLC19A2/A3 transporter that limits thiamine HCl absorption at high doses. Achieves ~5× higher RBC/tissue thiamine than equivalent HCl. Activates transketolase, redirecting triose phosphates away from AGE precursors.

Half-Life (t½)

PO: 5h

Dosing Guidelines

Target Organ Systems

Interactions