Oxcarbazepine

Category: pharmacological

Aliases: Trileptal

Pharmacological Mechanism

Carbamazepine analog — voltage-gated Na+ channel blocker. Active 10-MHD metabolite. Less CYP induction than carbamazepine + no auto-induction → cleaner DDI profile. Hyponatremia in 2.5% (more than carbamazepine).

Half-Life (t½)

PO: 9h

Dosing Guidelines

• PO: Typical 1200mg (Range: 300 - 2400 mg)

Target Organ Systems

• nervous

Interactions

• Hormonal contraceptives
• Felodipine